Many interesting talks heard since Tuesday (missed that of Monday)
best Biofilm researchers presenting their work
Thursday, June 4, 2020
The social biofilm network 2020
Currently attending The social biofilm network 2020 online via ZOOM from June 1-5
Tuesday, June 2, 2020
Acute vs chronic infections
These terms can be understood by taking the example of Pseudomonas aeruginosa as model organism.
ACUTE INFECTION
Acute infections are characterised by bacteria which can flow or motile. They have overexpression of virulence factors e.g. Type 3 secretion. During acute infection, bacteria can move in blood or through mucin layers.
CHRONIC INFECTIONS
Chronic infection is characterised by sessile bacterial colonies called biofilms.
ACUTE INFECTION
Acute infections are characterised by bacteria which can flow or motile. They have overexpression of virulence factors e.g. Type 3 secretion. During acute infection, bacteria can move in blood or through mucin layers.
CHRONIC INFECTIONS
Chronic infection is characterised by sessile bacterial colonies called biofilms.
Monday, June 1, 2020
Difference between MIC and MBEC for antibiotic experiments
MIC - Minimal inhibition concentration
The minimal concentration of antibiotic at which no bacterial growth is observed is called MIC. For instance, MIC of colistin for Pseudomonas aeruginosa ranges 1-2 ug/ml. The strains which can grow above MIC may be considered resistant or tolerant strains.
MBEC- Minimal Biofilm Eradication Concentration
The minimum concentration of antibiotic required to eradicate mature biofilms is termed as MBEC. In general, MBEC are higher than MIC e.g. Pseudomonas aeruginosa MBEC ranges >100 ug/ml colistin.
The minimal concentration of antibiotic at which no bacterial growth is observed is called MIC. For instance, MIC of colistin for Pseudomonas aeruginosa ranges 1-2 ug/ml. The strains which can grow above MIC may be considered resistant or tolerant strains.
MBEC- Minimal Biofilm Eradication Concentration
The minimum concentration of antibiotic required to eradicate mature biofilms is termed as MBEC. In general, MBEC are higher than MIC e.g. Pseudomonas aeruginosa MBEC ranges >100 ug/ml colistin.
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